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Dr. Johann S. de Bono, MD Abiraterone Acetate Significantly Improved Overall Survival for Patients with Metastatic Advanced Prostate Cancer

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Description: Results from a pre-specified interim analysis of a randomized, placebo controlled Phase 3 study, COU-AA-301, demonstrate that patients treated with the investigational agent abiraterone acetate plus low-dose prednisone/prednisolone showed a significant improvement in overall survival compared to patients treated with prednisone/prednisolone plus placebo. This study included 1,195 patients with metastatic advanced prostate cancer (also referred to as castration-resistant prostate cancer, or CRPC) previously treated with one or two chemotherapy regimens, at least one of which contained docetaxel.

Treatment with abiraterone acetate resulted in a 35 percent reduction in the risk of death
(HR=0.65; 95 percent CI: 0.54, 0.77; p<0.0001) and a 36 percent increase in median survival
(14.8 months vs. 10.9 months) compared with placebo.
Shared By : europe_meeting_2010
Posted on : 10/11/10
Added : 7 years ago
Category : Prostate Cancer



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