Regulation of Intestinal Inflammation by Microbiota following Allogeneic Bone Marrow Transplantation

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Description: Medical oncologist Robert Jenq of Memorial Sloan-Kettering's Bone Marrow Transplant Service describes research published in the May 7, 2012, issue of the Journal of Experimental Medicine ( on the link between intestinal inflammation, intestinal bacteria, and the risk of graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation. Abdominal pain and diarrhea are among the many symptoms associated with GVHD, which occurs when the T cells from the bone marrow donor attack the tissues of the transplant recipient. Using a murine and human model, Dr. Jenq and investigators found that GVHD dramatically altered the composition of intestinal microbiota in both models, and that altering the microbiota by increasing Lactobacillus levels offers protection against GVHD. Their data suggests that flora manipulation may reduce intestinal inflammation and improve outcomes for allogeneic bone marrow transplant recipients, reducing the risk for GVHD.
Shared By : mskcc
Posted on : 02/20/13
Added : 5 years ago
Category : General


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