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Extrathymic Development of Murine T Cells Post--Bone Marrow Transplant -- Sloan-Kettering

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Description: T cell generation is impaired following allogeneic bone marrow transplantation because the thymus is damaged, and T cell reconstitution takes considerable time. Medical oncologist Marcel van den Brink describes results published in the December 2012 Journal of Clinical Investigation (www.ncbi.nlm.nih.gov/pubmed...) indicating that functioning T cells may be generated outside the thymus -- in abdominal (mesenteric) lymph nodes -- post--allogeneic bone marrow transplant. Using a murine model, van den Brink and colleagues challenged mice with various viruses and found that for a window of time, the extrathymic T cells were functional (capable of mounting an immune response). Van den Brink explains that these discoveries may generate a host of new strategies for boosting T cell function in patients who have had an allogeneic bone marrow transplant.
Shared By : mskcc
Posted on : 02/20/13
Added : 5 years ago
Category : General



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