Extrathymic Development of Murine T Cells Post--Bone Marrow Transplant -- Sloan-Kettering

mskcc has 134 videos Subscribe Here

Description: T cell generation is impaired following allogeneic bone marrow transplantation because the thymus is damaged, and T cell reconstitution takes considerable time. Medical oncologist Marcel van den Brink describes results published in the December 2012 Journal of Clinical Investigation ( indicating that functioning T cells may be generated outside the thymus -- in abdominal (mesenteric) lymph nodes -- post--allogeneic bone marrow transplant. Using a murine model, van den Brink and colleagues challenged mice with various viruses and found that for a window of time, the extrathymic T cells were functional (capable of mounting an immune response). Van den Brink explains that these discoveries may generate a host of new strategies for boosting T cell function in patients who have had an allogeneic bone marrow transplant.
Shared By : mskcc
Posted on : 02/20/13
Added : 5 years ago
Category : General

More From mskcc

Nothing found.