Description: Background: Elotuzumab, an immunostimulatory monoclonal antibody, has a dual mechanism of action: directly activating NK cells and tagging myeloma cells for recognition/death via antibody-dependent cell-mediated cytotoxicity. In a 3-y FU, ELOQUENT-2 (NCT01239797) showed a sustained 27% reduction in risk of disease progression/death for ELd vs Ld and OS trend in favor of ELd (Dimopoulos et al, ASH 2015). Here we present extended 4-y FU data (median FU 46 mo).
Author(s): Sagar Lonial, Meletios A. Dimopoulos, Katja C. Weisel, Darrell White, Philippe Moreau, Maria-Victoria Mateos, Jesus San Miguel, Kenneth Carl Anderson, Ofer Shpilberg, Sebastian Grosicki, Ivan Spicka, Adam Walter-Croneck, Hila Magen, Andrew Belch, Donna Ellen Reece, Meral Beksac, Sabeen Mekan, Oumar Sy, Anil K. Singhal, Paul G. Richardson; Winship Cancer Institute, Atlanta, GA; National and Kapodistrian University of Athens School of Medicine, Athens, Greece; University of Tübingen, Tübingen, Germany; Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada; University Hospital, Nantes, France; University Hospital of Salamanca–Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Clínica Universidad de Navarra, Pamplona, Spain; Dana-Farber Cancer Institute, Boston, MA; Institute of Haematology, Assuta Medical Centers, Tel-Aviv, Israel; Medical University of Silesia, Katowice, Poland; Charles University in Prague and General Teaching Hospital, Prague, Czech Republic; Medical University of Lublin, Lublin, Poland; Davidoff Cancer Center, Petah Tikva, Israel; Cross Cancer Institute, Edmonton, AB, Canada; Princess Margaret Hospital, Toronto, ON, Canada; Ankara University, Ankara, Turkey; Bristol-Myers Squibb, Lawrenceville, NJ; AbbVie Inc., Redwood City, CA
Clinical trial information: NCT01239797