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    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events
    00:07:46

    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events

    Aung Naing, MD, FACP MD Anderson speaks about Strategies for improving the management of immune-related adverse events.

    You can download the IO Tox Management below -
    IOS -
    https://apps.apple.com/us/app/io-tox-management/id1514006592

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    You can find the full Abstract through the link below -
    https://jitc.bmj.com/content/8/2/e001754.full



    Instract
    Durable and drastic responses in many difficult-to-treat malignancies have been observed with the advent of immunotherapeutic agents, outlining a path to overcoming cancer. Immune checkpoint inhibitors (ICPi) are a class of immunotherapy agents that, by reinvigorating the suppressed immune system, attack tumor cells. However, unbridled T-cell activity disrupts immune homeostasis and, in a large proportion of patients, causes a unique spectrum of side effects termed immune-related adverse events (irAEs). These irAEs vary from the side effects that conventional chemotherapeutic agents create. Life-threatening and fatal incidents have been recorded, but the majority of irAEs are manageable with corticosteroids and other immunosuppressive agents. Management of irAEs has been difficult for patients, clinicians, and healthcare providers alike, in the absence of predictive biomarkers to classify patients at risk for irAEs and a systematic method to diagnose, report and treat irAEs. The incidence of irAEs would inevitably increase with the growing use of ICP is for the treatment of different cancers. There is a compelling need to implement strategies, both in community settings and in cancer centers, to handle irAEs effectively. To this end, we propose several strategies in this paper, such as providing patient education, harmonizing the guidelines for irAE management, standardizing irAE reporting, improving the selection of immunosuppressive agents, conducting preclinical, clinical, and translational studies to better understand irAEs, including high-risk patients, integrating diagnostic tools to personalize irAE management.

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    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events
    00:07:46

    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events

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    6 days ago
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    Prakash Bhuyan, MD on VGX-3100 Efficacy Results and Important Points @InovioPharma Prakash Bhuyan, MD on VGX-3100 Efficacy Results and Important Points @InovioPharma
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    Prakash Bhuyan, MD on VGX-3100 Efficacy Results and Important Points @InovioPharma

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    Nicholas Vogelzang, MD on Phase 2 TRITON2 Clinical Trial @CCCNevada Nicholas Vogelzang, MD on Phase 2 TRITON2 Clinical Trial @CCCNevada
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    Vivek Subbiah, MD on RET inhibitorr: Common Questions @VivekSubbiah #ASCO2020 @MDAndersonNews #ASCO Vivek Subbiah, MD on RET inhibitorr: Common Questions @VivekSubbiah #ASCO2020 @MDAndersonNews #ASCO
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    Vivek Subbiah, MD on RET inhibitorr: Advanced in the Study @VivekSubbiah #ASCO2020 @MDAndersonNews #ASCO Vivek Subbiah, MD on RET inhibitorr: Advanced in the Study @VivekSubbiah #ASCO2020 @MDAndersonNews #ASCO
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    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events
    00:07:46

    Aung Naing, MD, FACP @ANaingMD @MDAndersonNews #adverseevents #Cancer #Research Strategies for improving the management of immune-related adverse events

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    6 days ago
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    R. Stephanie Huang, Ph.D. @huang_lab @UMN_ECP @UMNews #Cancer #Research Computationally predicting clinical drug combination efficacy R. Stephanie Huang, Ph.D. @huang_lab @UMN_ECP @UMNews #Cancer #Research Computationally predicting clinical drug combination efficacy
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    R. Stephanie Huang, Ph.D. @huang_lab @UMN_ECP @UMNews #Cancer #Research Computationally predicting clinical drug combination efficacy

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    Ron Peck, MD @ArvinasInc #BreastCancer #ProstateCancer #ARV471 #ARV110 #Cancer #Research Protein Degraders ARV-471 and ARV-110 Ron Peck, MD @ArvinasInc #BreastCancer #ProstateCancer #ARV471 #ARV110 #Cancer #Research Protein Degraders ARV-471 and ARV-110
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    @CardioOncology @BalkoLab @VUMC_Cancer @VUMCHemOnc @VUMChealth #Myocarditis #CardioOnc #CancerImmunotherapy #Cancer #Research A genetic mouse model recapitulates immune checkpoint inhibit... @CardioOncology @BalkoLab @VUMC_Cancer @VUMCHemOnc @VUMChealth #Myocarditis #CardioOnc #CancerImmunotherapy #Cancer #Research A genetic mouse model recapitulates immune checkpoint inhibit...
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    Gelareh Zadeh, M.D., Ph.D @gelarehzadeh @DNAtrixInc #SNO20 #Neuro-oncology #Cancer #Research Positive Data from Phase 2 CAPTIVE (KEYNOTE-192) Study with DNX-2401 Gelareh Zadeh, M.D., Ph.D @gelarehzadeh @DNAtrixInc #SNO20 #Neuro-oncology #Cancer #Research Positive Data from Phase 2 CAPTIVE (KEYNOTE-192) Study with DNX-2401
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    Steven W. Pipe, MD @MiPipeline @UMich #Hemophilia #Cancer #Research Gene Therapy for Hemophilia B Found Safe and Effective in First Phase III Trial Steven W. Pipe, MD @MiPipeline @UMich #Hemophilia #Cancer #Research Gene Therapy for Hemophilia B Found Safe and Effective in First Phase III Trial
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    Clint Valentine, MS @clintcodesbio @TwinStrandBio #CancerDetection #Cancer #Research Study Results Highlighting Ability of Duplex Sequencing Technology Clint Valentine, MS @clintcodesbio @TwinStrandBio #CancerDetection #Cancer #Research Study Results Highlighting Ability of Duplex Sequencing Technology
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    Jyoti Nangalia, MBBChir @jyoti_nangalia @sangerinstitute @SCICambridge @CUH_NHS@Cambridge_Uni #MyeloidMalignancies #bloodcancer #Cancer #Research  LBA-1 Driver Mutation Acquisition in Ute... Jyoti Nangalia, MBBChir @jyoti_nangalia @sangerinstitute @SCICambridge @CUH_NHS@Cambridge_Uni #MyeloidMalignancies #bloodcancer #Cancer #Research  LBA-1 Driver Mutation Acquisition in Ute...
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    Brian Van Tine, MD, Ph.D. @bvantine1 @WUSTLmed #Sarcoma #Cancer #Research Spearhead 1 Study Brian Van Tine, MD, Ph.D. @bvantine1 @WUSTLmed #Sarcoma #Cancer #Research Spearhead 1 Study
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    John Mascarenhas, MD @TischCancer @IcahnMountSinai #ASH20 #Myelofibrosis #Cancer #Research Update of MANIFEST Phase 2 Study John Mascarenhas, MD @TischCancer @IcahnMountSinai #ASH20 #Myelofibrosis #Cancer #Research Update of MANIFEST Phase 2 Study
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