Liquid Biopsy Highly Accurate in Detecting Early-Stage Colorectal Cancer Overview

Liquid Biopsy Highly Accurate in Detecting Early-Stage Colorectal Cancer Overview

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Kathryn Lang, MD of Guardant Health provides an overview of data presented at AACR 2020 that shows that the LUNAR-2 assay achieved 90% sensitivity and 94% specificity in detecting early-stage CRC.1 When restricting analysis of the controls to those who were negative for CRC by colonoscopy (n=74), the LUNAR-2 assay demonstrated improved specificity (99%) with no reduction in sensitivity. These results are consistent with previously reported data2 showing that the company’s multi-modal, cancer-specific circulating tumor DNA (ctDNA) technology increases test sensitivity to deliver clinically meaningful results.

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