In this interview, Jeff Evans, PhD, from the University of Glasgow, Glasgow, UK, provides an update on the current landscape of pancreatic cancer. Prof. Evans discusses the challenges of treating pancreatic cancer and the lack of therapeutic options due to high resistance to most systemic treatments. He highlights how studies are now focusing on immunotherapy, the tumor microenvironment and establishing the best biomarkers for diagnostics. He identifies a new set of trials looking at this under the Precision Panc initiative, which are keen on adapting and combining these new therapies with novel agents. This video was recorded at the Oncology Forum (OF) 2018, held in Liverpool, UK.