What is the role of allogeneic stem cell transplantation in CLL in the light of novel drugs?

What is the role of allogeneic stem cell transplantation in CLL in the light of novel drugs?

VJHemOnc

3 years
970 Views
Share
Want to watch this again later?
Sign in to add this video to a playlist. Login
0 0
Category:
Description:
John Gribben, MD, DSc, FRCPath, FMed Sci of Barts Cancer Institute, London, UK discusses the place of allogeneic stem cell transplantation in chronic lymphocytic leukemia (CLL) at the 2016 International Workshop of the German CLL Study Group (GCLLSG) in Cologne, Germany. Prof. Gribben points out that allogeneic stem cell transplantation is the only curative treatment available in CLL. However, only a small population of patients can receive a transplant due to age and it is associated with morbidity (specifically from graft-versus-host-disease) and mortality. When the choice was between a transplant or having no effective salvage therapy, the decision was more clear-cut. With the advent of new drugs with high response rates and good duration of response as well as toxicity profiles, it is becoming less clear where an allogeneic stem cell transplant fits into the management of CLL. There are guidelines available but there is no clear consensus and no sufficient data on this question. As Prof. Gribben explains, it is important not to miss the window in which a transplant would be useful. Finally, Prof. discusses how with idelalisib, ibrutinib and venetoclax now available to salvage the high-risk patients, the transplant is again moved further back in the treatment of CLL.
Up Next Autoplay
Lower Costs for Patients in Metastatic Breast Cancer
Lower Costs for Patients in Metastatic Breast Cancer
Category: Breast Cancer
1 Views
ONeal Comprehensive Cancer Center 7 hours
New Technology to Streamline Drug Discovery
New Technology to Streamline Drug Discovery
Category: Other
2 Views
Cancer-News 1 day
Using Technology to Better Understand What Goes Wrong in Cancer
Using Technology to Better Understand What Goes Wrong in Cancer
Category: Breast Cancer
1 Views
Cancer-News 1 day
How Does This Affect Clinicians Today?
How Does This Affect Clinicians Today?
Category: Breast Cancer
1 Views
Cancer-News 1 day
Measuring Chromatin Accessibility: How Reliable is This Data?
Measuring Chromatin Accessibility: How Reliable is This Data?
Category: Breast Cancer
1 Views
Cancer-News 1 day
Dual-function Virus Designed For Killing Tumor Cells and Helping Immune Cells
Dual-function Virus Designed For Killing Tumor Cells and Helping Immune Cells
Category: Melanoma and Skin Cancer
3 Views
Cancer-News 1 day
Mapping the usual breast development to recognize cancer better
Mapping the usual breast development to recognize cancer better
Category: Breast Cancer
4 Views
Cancer-News 1 day
Metformin: How Does This Affect Treatment?
Metformin: How Does This Affect Treatment?
Category: Ovarian Cancer
5 Views
Cancer-News 1 day
New Frontier Possibility for Preventing Ovarian Cancer
New Frontier Possibility for Preventing Ovarian Cancer
Category: Ovarian Cancer
3 Views
Cancer-News 1 day
"Wild idea" opens possible new boundaries to ovarian cancer prevention
Category: Ovarian Cancer
5 Views
Cancer-News 1 day